WebSep 27, 2024 · It is not uncommon for people to experience insomnia while taking bactrim. This is because the medication can cause the body to become agitated and restless. If you are taking bactrim and experience insomnia, it is important to talk to your doctor. They may be able to prescribe a different medication that will not cause this side effect. WebNote: This medicine also comes in double strength tablets (Bactrim DS and Septra DS) with 800 mg. sulfamethoxazole and 160 mg. trimethoprim. Use half the number of tablets given below if the medicine you have is double strength.
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