Webtraditional and innovative approaches to promote drug permeation through the cornea. As the effectiveness of inulin-based (simple or PEGylated) polymeric micelles to act as successful ocular permeation enhancers was already reported [13,14], in this study an improvement in terms of efficacy was proposed by the use of taurine, carnitine, and WebSome mucoadhesive polymers are multifunctional excipients, so they act by different mechanisms on increasing the permeability of the cornea. Additionally, many hydrophilic …
Full article: Ocular lamellar crystalline gels for sustained release ...
WebHuman corneal epithelial cells (HCEpC) have been used as models for studying corneal damage and reconstruction, re-epithelialization of the eye following surgery, and the effects of degradative enzymes. Corneal research mainly focuses on developing a model of drug permeation through this structure . The models of corneal culture used in ... WebOn the other hand, the high permeation from the optimized formulations could be explained by their nanosize in addition to the presence of PF127 acting as a permeation enhancer through the cornea. 89 Furthermore, the selected lyophilized formula (L3) showed a higher drug permeation rate and extent than the OIG formulation. The low ex vivo drug ... grape snow cone lyrics
Role of mucoadhesive agent in ocular delivery of ganciclovir
WebAug 1, 2001 · Human corneas, unsuitable for transplantation, were either freshly used for permeability experiments or snap-frozen in liquid nitrogen and stored at -85 degrees C. CsA permeation through either... WebSep 9, 2024 · Permeation enhancers are functional excipients that are included in the formulations to improve the absorption of the active molecule. Ocular permeation … WebJan 23, 2012 · For adequate drug permeation from the aqueous tear fluid through cornea into aqueous humour, the permeating drug molecule must, in general, be both sufficiently hydrophilic to be soluble in the tear fluid and sufficiently lipophilic to … grape snack recipes