Web1 apr. 2008 · Introduction. The monitoring of therapeutic drugs involves measuring drug concentrations in plasma, serum or blood. This information is used to individualise dosage so that drug concentrations can be maintained within a target range. 1. Drug concentration at the site of action cannot be routinely measured, but the desired or adverse effects may ... Web6 mei 2024 · Lithium and Brain Derived Neurotrophic Factor. Brain derived neurotrophic factor (BDNF) is a growth factor for neurons. Discovered in 1982 in samples of brain tissue from pigs, the growth factor has been shown to promote survival, growth, development and plasticity of nerve cells (Barde 1982, Huang 2001). Since its discovery, …
Lithium for acute mania - PMC - National Center for …
WebSemisodium valproate (Depakote ®) is licensed for the treatment of acute mania (but is not licensed for use in children). Sodium valproate (Epilim ®) and valproic acid (Convulex ®) are both unlicensed for the treatment of bipolar disorder. Both semisodium and sodium valproate are metabolized to valproic acid, which is responsible for their ... WebTherapeutic serum-lithium concentrations are within the range of 0.4–1 mmol/litre; concentrations in excess of 2 mmol/litre are usually associated with serious toxicity and … dynamic twitter header
Serum lithium test requesting across three UK regions: an evaluati…
WebDiscussion. Therapeutic drug monitoring is generally only indicated when medications have specific characteristics (eg. a narrow therapeutic index), where there is an established therapeutic range, where the consequences of undertreatment cannot be recognised clinically and can be serious (eg. seizure) and/or if toxicity is suspected. WebThe total daily maintenance dose of a drug can be reduced either by reducing the size of the individual doses or by increasing the interval between doses. For some drugs, … Web18 aug. 2024 · A range of 5 to 15 micrograms/ml may be effective, and associated with fewer adverse effects. The dosage should be titrated for each individual and adjusted with caution. Serum theophylline levels should be monitored to ensure that they remain within the therapeutic range. During therapy, patients should be monitored carefully for signs of ... cs 1.6 knife animation