WebMar 19, 2024 · In that study, it was found that daptomycin vs standard of care yielded a 12.6% difference in treatment success (95% confidence interval, –7.4% to 32.6%), favoring daptomycin for MRSA; however, this was confounded by addition of gentamicin to the standard care group. WebJun 12, 2024 · Four studies (n = 853) compared vancomycin combined with a gram-negative antibiotic: vancomycin with oritavancin (aztreonam allowed in both arms), 38 vancomycin plus aztreonam with ceftaroline fosamil, 16,17 and vancomycin plus ceftazidime with ceftobiprole medocaril. 39 No difference was found between …
Narrative Review of Early Oral Stepdown Therapy for the …
WebAug 12, 2024 · The current standard therapy for MRSA bacteremia is vancomycin or daptomycin. 4 Vancomycin has many shortcomings, including poor tissue penetration and slow killing time. … WebThere was no significant difference in the length of MRSA bacteremia. Variables independently associated with treatment failure included … training puppy to leash walk
Daptomycin as Frontline Therapy for MRSA Bacteremia: …
WebNov 5, 2013 · Our primary hypothesis is that Daptomycin treatment is superior to vancomycin treatment in reducing mortality from BSIs due to MRSA with high vancomycin MIC from 25% to 10%. Detailed Description: Introduction/Clinical Significance Vancomycin is the standard first-line treatment for methicillin resistant Staphylococcus aureus … WebAug 23, 2024 · Daptomycin (Cubicin) is a cyclic lipopeptide antibiotic with broad-spectrum gram-positive activity, including methicillin-resistant Staphylococcus … WebOct 19, 2024 · Daptomycin 2,3 8 mg/kg IV daily or Vancomycin 2 15 mg/kg IV every 12 hours (adjust dose based on levels) Second Line4: Ceftaroline 2 600 mg IV every 8 hours Telavancin 2 7.5 mg/kg (maximum 750 mg) IV daily Methicillin resistant S. aureus? MRSA bacteremia MSSA bacteremia Therapy duration: 4-6 weeks IV therapy from first … training puppy to fetch