Chk1 ps345
WebPhospho-Chk1 (Ser345) Antibody detects endogenous levels of Chk1 only when phosphorylated at serine 345. This antibody does not cross-react with Chk1 when phosphorylated at other sites. Species Reactivity: Human, … WebMay 7, 2024 · Upon UV exposure or replication stress, CHK1 is activated through phosphorylation of its S317 and S345 residues by the upstream kinase ATR ( 4 ). Once activated, CHK1 phosphorylates an array of downstream substrates to modulate various cellular processes after DNA damage ( 5, 6 ).
Chk1 ps345
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WebPhospho-CHK1 (Ser345) Antibody (MA5-45974) in ICC/IF. Immunofluorescence analysis of CHK1 (pS345) was performed using 70% confluent log phase HeLa cells treated with 5 μM Etoposide for 16 hrs. The cells were fixed with 4% Paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 45 ... WebJun 1, 2011 · Of the biomarkers assessed, pS345 Chk1 was most consistently increased in response to gemcitabine and AZD7762 in tumors and normal tissues (hair follicles). …
WebBackground. Chk1 kinase acts downstream of ATM/ATR kinase and plays an important role in DNA damage checkpoint control, embryonic development, and tumor suppression (1). … http://www.ruixibiotech.com/pts/ps345-chk1
WebMar 29, 2024 · The levels of c-Myc, pS296-CHK1 and pS345-CHK1 as PD biomarkers of CHK1 inhibition were evaluated in four sensitive cell lines (Z138, MV411, CCRF-CEM, … WebChk1_pS345-R-C Chk1_pS345 CHEK1 Use with Caution Rabbit CST 2348 Chk2-M-E Chk2 CHEK2 Validated Mouse CST 3440 Chk2_pT68-R-E Chk2_pT68 CHEK2 Use with Caution Rabbit CST 2197 cIAP-R-V cIAP BIRC2 Use with Caution Rabbit Millipore 07-759 Claudin-7-R-V Claudin-7 CLDN7 Validated Rabbit Novus NB100-91714
WebWe also found that pS345 Chk1, which is a measure of DNA damage, was induced in marker-positive cells but not in the marker-negative cells. These data demonstrate that Chk1 inhibition in combination with gemcitabine reduces both the percentage and the tumor-initiating capacity of pancreatic cancer stem cells. Furthermore, the finding that the ...
WebSep 11, 2024 · The exploratory ROC analysis revealed five proteins (4E-BP1_pT70, Chk1_pS345, Snail, STAT5 alpha and PAI-1) with an AUC greater than 0.75 in … photo hunt videoWebFive proteins (4E-BP1_pT70, Chk1_pS345, Snail, STAT5 alpha and PAI-1) were significantly associated with survival, and their use as a panel refined the risk stratification independently from the AJCC staging, with a hazard ratio for a positive result of 21.2 (95%CI 3.7-122.2, P = 0.0006). how does gulliver feel about warWebJul 1, 2024 · The Chk1 pS345 signal was normalized to that of Chk1; subsequently, the ratio of Chk1 pS345 upregulation was normalized to that detected in non-irradiated cells. PD-L1 quantification in C was performed as described in Fig. 1. Quantification of mRNA expression levels by real-time PCR photo hunt walkoutWebJun 1, 2011 · In contrast, in normal tissues pS345 Chk1 appears to be a fairly rapid and short-lived response that is sensitive to the gemcitabine and AZD7762 doses. These findings suggest that pS345 Chk1 is a much more robust response in tumor than in normal tissue, which is consistent with the selective toxicity against tumors observed in our … how does gulliver spy on blefuscuWebIt has been suggested that AZD7762 treatment impairs CHK1 autophosphorylation (S296 CHK1), stabilizes CDC25A and potentiates the ATR/ATM-mediated CHK1 … photo hosting service phphow does gulliver end up stranded in lilliputWebSpecific for Chk1 (phospho S345) in ELISA, with <1% reactivity with the non-modified form of the immunogen. Tested applications Suitable for: WB, IHC-P, ELISA more details … how does gulliver put out the fire